邮  箱:oygldz@xmu.edu.cn

职称/职务:教授 博士生导师


  • 个人简介
  • 科研领域
  • 代表性成果


B.S. 1993, Nanchang University, Biology;
M.S. 1998, Xiamen University, Biology;
Ph.D. 2001, Xiamen University, Zoology;
Associate Professor/Professor, School of Life Sciences, Xiamen University, 2010 to present.


Tumor metastasis is a complex multi-step process, involving dissemination of cancer cells to distant organ sites and their subsequent adaptation to and remodeling of foreign tissue microenvironments. Our research group is mainly devoted to the study of tissue microenvironment and tumor metastasis, and have elucidated the function of periostin in inflammatory microenvironments and tumor microenvironments and its regulatory role in tumor metastasis. We will continue to investigate the mechanisms of periostin and other matricellular proteins in tissue microenvironment remodeling and tumor metastasis.

20700app大阳城下载:代表性论文(# co-first author, * Corresponding author):

1. Xiao H, Zhang Y, Li Z, Liu B, Cui D, Liu F, Chen D*, Liu Y*, Ouyang G*. Periostin deficiency reduces diethylnitrosamine-induced liver cancer in mice by decreasing hepatic stellate cell activation and cancer cell proliferation. J Pathol, 2021; 255(2): 212-223.
2. Ma H, Wang J, Zhao X, Wu T, Huang Z, Chen D, Liu Y*, Ouyang G*. Periostin promotes colorectal tumorigenesis through integrin-FAK-Src pathway-mediated YAP/TAZ activation. Cell Rep, 2020; 30(3): 793-806.e6.
3. Ma Z, Zhao X, Deng M, Huang Z, Wang J, Wu Y, Cui D, Liu Y, Liu R*, Ouyang G*. Bone marrow mesenchymal stromal cell-derived periostin promotes B-ALL progression by modulating CCL2 in leukemia cells. Cell Rep, 2019; 26(6): 1533-1543.e4.
4. Wu T, Huang J, Wu S, Huang Z, Chen X, Liu Y, Cui D, Song G, Luo Q, Liu F*, Ouyang G*. Deficiency of periostin impairs liver regeneration in mice after partial hepatectomy. Matrix Biol, 2018; 66: 81-92.
5. Ma Z, Zhao X, Huang J, Jia X, Deng M, Cui D, Du Z, Fu G*, Ouyang G*, Xiao C*. A critical role of periostin in B-cell acute lymphoblastic leukemia. Leukemia, 2017; 31(8): 1835-1837.
6. Wang Z, Xiong S, Mao Y, Chen M, Ma X, Zhou X, Ma Z, Liu F, Huang Z, Luo Q, Ouyang G*. Periostin promotes immunosuppressive premetastatic niche formation to facilitate breast tumour metastasis. J Pathol, 2016; 239(4): 484-495.
7. Li Y, Wu S, Xiong S, Ouyang G*. Deficiency of periostin protects mice against methionine-choline-deficient diet-induced nonalcoholic steatohepatitis. J Hepatol, 2015; 62(2): 495-497.
8. Wu T, Luo Q*, Ouyang G*. Periostin: a potent chemotactic factor for recruiting tumor-associated macrophage. Protein Cell, 2015; 6(4): 235-237.
9. Wu T, Wu S, Ouyang G*. Periostin: a new extracellular regulator of obesity-induced hepatosteatosis. Cell Metab, 2014; 20(4): 562-564. (Preview)
10. Liu AY, Zheng H, Ouyang G*. Periostin, a multifunctional matricellular protein in inflammatory and tumor microenvironments. Matrix Biol, 2014; 37: 150-156.
11. Wu T, Ouyang G*. Matricellular proteins: multifaceted extracellular regulators in tumor dormancy. Protein Cell, 2014; 5: 249-252.
12. Liu AY, Ouyang G*. Tumor angiogenesis: glioblastoma stem cells as a new source of pericytes. Curr Biol, 2013; 23(13): R565-R568.
13. Wang Z, Ouyang G*. Periostin: a bridge between cancer stem cells and their metastatic niche. Cell Stem Cell, 2012; 10(2): 111-112. (Preview)
14. Fang X, Cai Y, Liu J, Wang Z, Wu Q, Zhang Z, Yang CJ, Yuan L, Ouyang G*. Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal. Oncogene, 2011; 30(47): 4707-4720.
15. Bao S, Ouyang G, Bai X, Huang Z, Ma C, Liu M, Shao R, Anderson RM, Rich JN, Wang XF*. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell, 2004; 5(4): 329-339.