邮  箱:zhangyalin@xmu.edu.cn

职称/职务:教授 博士生导师


  • 个人简介
  • 科研领域
  • 代表性成果


B.S. 2008, Xiamen University, Biological Sciences;
Ph.D. 2013, Xiamen University, Biochemistry and Molecular Biology;
Postdoctoral Fellow, Albert Einstein College of Medicine, 2014-2018;
Professor, School of Life Sciences, Xiamen University, 2018 to Present.


The hypothalamus connects the neurological and endocrine systems, regulates appetite, glucose metabolism and body temperature, and plays a vital role in maintaining homeostasis. We focus on the mechanism of hypothalamic regulation of energy metabolism homeostasis and aging, especially the functions of neuroinflammation, neurosecretory and epigenetic factors in the development of metabolic syndrome and neurodegeneration.

20700app大阳城下载:代表性论文(# co-first author, * Corresponding author):

1. Zhang Y#, Kim MS#, Jia B#, Yan J#, Zuniga-Hertz JP, Han C, Cai D. Hypothalamic stem cells control aging speed partly through exosomal miRNAs. Nature. 2017 Aug 3;548(7665):52-57.
2. Zhang Y, Reichel JM, Han C, Zuniga-Hertz JP, Cai D. Astrocytic process plasticity and IKKβ/NF-κB in central control of blood glucose, blood pressure and body weight. Cell Metabolism. 2017 May 2;25(5):1091-1102.
3. Ale A, Zhang Y, Han C, Cai D. Obesity-associated extracellular mtDNA activates central TGFβ pathway to cause blood pressure increase. Am J Physiol Endocrinol Metab. 2016 Nov 15:ajpendo.00337.2016.
4. Kim MS, Yan J, Wu W, Zhang G, Zhang Y, Cai D. Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis. Nature Immunology. 2015 May;16(5):525-33.
5. Zhang Y, Liu G, Yan J, Zhang Y, Li B, Cai D. Metabolic learning and memory formation by the brain influence systemic metabolic homeostasis. Nature Communications. 2015 Apr 7;6:6704.
6. Zhang CS, Jiang B, Li M, Zhu M, Peng Y, Zhang Y, Wu YQ, Li TY, Liang Y, Lu Z, Lian G, Liu Q, Guo H, Yin Z, Ye Z, Han J, Wu JW, Yin H, Lin SY, Lin SC. The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism. Cell Metabolism. 2014 Sep 2;20(3):526-40.
7. Zhang Y#, Guo H#, Zhang CS#, Lin SY, Yin Z, Peng Y, Luo H, Shi Y, Lian G, Zhang C, Li M, Ye Z, Ye J, Han J, Li P, Wu JW, Lin SC. AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metabolism. 2013 Oct 1;18(4):546-55.