邮  箱:jfyuan@xmu.edu.cn

职称/职务:教授 博士生导师


  • 个人简介
  • 科研领域
  • 代表性成果


B.E. 2007, Xi’an Jiaotong University, Bioengineering;
Ph.D. 2012, Nanyang Technological University, Biomedical Engineering;
Research Scientist, National University of Singapore, 2012-2016;
Senior Research Fellow, Agency for Science, Technology and Research, 2016-2017;
Research Fellow, National University of Singapore, 2017-2018;
Professor, Xiamen University, 2018 to Present.


a) 代谢工程优化细胞工厂;
b) 级联生物催化途径的设计与开发;
c) 生物传感器的设计与开发;
d) 植物天然产物生源途径的解析与微生物异源合成;
e) 益生菌的精准设计与疾病治疗。
KEYWORDS: Synthetic Biology, Metabolic Engineering, Biosensor, Probiotics, Genome Editing, Natural Products, Bio-manufacturing.
By employing synthetic biology and metabolic engineering principles, our group focuses on devising efficient microbial cell factory for chemical productions, elucidating the biosynthetic pathways of natural products, developing biosensors for pathogen detection and probiotics-based disease treatment. More specifically, a) metabolic engineering toward more efficient cell factories; b) cascaded enzyme catalysis; c) biosensor design; d) pathway elucidation and microbial synthesis of plant natural products; e) probiotics-based disease treatment.

20700app大阳城下载:代表性论文(# co-first author, * Corresponding author):

1. Lingrui Liu, Lu Zhang, Junyi Wang, Mingfeng Cao*, Jifeng Yuan*. Copper-inducible expression system for metabolic engineering of Escherichia coli. 2022, doi: 10.21203/rs.3.rs-2367813/v1
2. Yang Zhang,Jifeng Yuan*.Harnessing photosynthetic bacterium for light-powered biocatalysis. 2022, doi:10.1101/2022.12.20.521182
3. Yanlin Li, Jing Wang, Linyong Li, Wenhui Song, Min Li, Xin Hua, Yu Wang, Jifeng Yuan*, Zheyong Xue*. Natural products of pentacyclic triterpenoids: from the discovery to heterologous biosynthesis. Natural Product Reports, 2022,doi:10.1039/d2np00063f
4. Qiwen Mo, Wei Song, Zheyong Xue*, Jifeng Yuan*. Multi-level engineering of Saccharomyces cerevisiae for synthesis and accumulation of retinal. Green Chemistry, 2022, 24, 8259-8263
5. Jifeng Yuan*#, Jie Cheng#, Cong Fan, Peiling Wu, Yang Zhang, Mingfeng Cao, Tuo Shi*. Development of shuttle vectors for rapid prototyping of engineered Synechococcus sp. PCC 7002. Applied Microbiology and Biotechnology, 2022, 106 (24), 8169-8181
6. Taiwei Yang, Peiling Wu, Yang Zhang, Mingfeng Cao, Jifeng Yuan*. High-titre production of aromatic amines in metabolically engineered Escherichia coli. Journal of Applied Microbiology, 2022,133,2931-2940
7. Cong Fan#, Danli Zhang#, Qiwen Mo, Jifeng Yuan*. Engineering Saccharomyces cerevisiae-based biosensors for copper detection. Microbial Biotechnology, 2022, 15, 2854-2860
8. Yang Zhang*, Jie Cheng, Yuting He, Jifeng Yuan*. Photo-fermentative hydrogen production performance of a newly isolated Rubrivivax gelatinosus YP03 strain with acid tolerance. International Journal of Hydrogen Energy, 2022, 47(48), 20784-20792
9. Wei Song#, Chunchun Zhang#, Jiali Wu, Jianzhao Qi, Xin Hua, Liping Kang*, Qiang Yuan*, Jifeng Yuan*, Zheyong Xue*. Characterization of three Paris polyphylla glycosyltransferases from different UGT families for steroid functionalization. ACS Synthetic Biology, 2022, 11(4), 1669-1680
10. Yuling Zhu, Jifeng Yuan*. A Four-Step Enzymatic Cascade for Efficient Production of L-Phenylglycine from Biobased L-Phenylalanine. ChemBioChem, 2022, 23(8), e202100661
11. Yumeng Lai#, Haofeng Chen#, Lingrui Liu#, Bixia Fu, Peiling Wu, Wanrong Li, Junyan Hu, Jifeng Yuan*. Engineering a Synthetic Pathway for Tyrosol Synthesis in Escherichia coli. ACS Synthetic Biology, 2022, 11(1), 441–447
12. Yueyang Chen, Yufen Chen, Lijun Liu, Yang Zhang, Jifeng Yuan*. Microbial synthesis of 4-hydroxybenzoate from renewable feedstocks. Food Chemistry: Molecular Sciences, 2021, 3, 100059
13. Bixia Fu, Gezhi Xiao, Yang Zhang, Jifeng Yuan*. One-Pot Bioconversion of Lignin-Derived Substrates into Gallic Acid. Journal of Agricultural and Food Chemistry, 2021, 69(38), 11336–11341
14. Bixia Fu#, Gezhi Xiao#, Yuling Zhu, Yueyang Chen, Yumeng Lai, Jifeng Yuan*. Renewable Vanillylamine Synthesis from Lignin-Derived Substrates. ACS Agricultural Science and Technology, 2021,1(5), 566–571
15. Yang Zhang, Xiaohui Song, Yumeng Lai, Qiwen Mo, Jifeng Yuan*. High-yielding terpene-based biofuel production in Rhodobacter capsulatus. ACS Synthetic Biology, 2021, 10(6), 1545–1552
16. Yufen Chen#, Bixia Fu#, Gezhi Xiao, Liang-Yu Ko, Tzu-Yu Kao, Cong Fan, Jifeng Yuan*. Bioconversion of Lignin-Derived Feedstocks to Muconic Acid by Whole-Cell Biocatalysis. ACS Food Science and Technology, 2021, 1(3), 382–387
17. Yang Zhang, Jifeng Yuan*. CRISPR/Cas12a-mediated genome engineering in the photosynthetic bacterium Rhodobacter capsulatus. Microbial Biotechnology, 2021, 14(6), 2700–2710
18. Qiwen Mo#, Huiyu Chen#, Cong Fan#, Danli Zhang, Lingrui Liu, Bixia Fu, Jifeng Yuan*. Utilization of a styrene-derived pathway for 2-phenylethanol production in budding yeast. Applied Microbiology and Biotechnology, 2021, 105(6), 2333-2340
19. Jifeng Yuan*, Qiwen Mo, Cong Fan. New Set of Yeast Vectors for Shuttle Expression in Escherichia coli. ACS Omega, 2021, 6(10), 7175–7180
20. Peiling Wu#, Yufen Chen#, Mingyu Liu, Gezhi Xiao, Jifeng Yuan*. Engineering an Optogenetic CRISPRi Platform for Improved Chemical Production. ACS Synthetic Biology, 2021, 10(1), 125-131
21. Yuling Zhu#, Taiwei Yang#, Yueyang Chen, Cong Fan, Jifeng Yuan*. One-Pot Synthesis of Aromatic Amines via Whole-Cell Biocatalysis. Chemistryselect, 2020, 5, 14292-14295
22. Yufen Chen#, Peiling Wu#, Liang-Yu Ko, Tzu-Yu Kao, Lijun Liu, Yang Zhang, Jifeng Yuan*. High-yielding protocatechuic acid synthesis from L-tyrosine in Escherichia coli. ACS Sustainable Chemistry and Engineering, 2020, 8(39), 14949-14954
23. Baiyun Zeng#, Yumeng Lai#, Lijun Liu, Jie Cheng, Yang Zhang, Jifeng Yuan*. High-yielding hydroxytyrosol synthesis from biobased L-tyrosine via cascade biotransformation. Journal of Agricultural and Food Chemistry, 2020, 68(29), 7691–7696
24. Zuoxi Mao#, Lijun Liu#, Yang Zhang#, Jifeng Yuan*. Efficient Synthesis of Phenylacetate and 2-Phenylethanol via One-Pot Cascade Biocatalysis. ChemBioChem, 2020, 21(18), 2676-2679
25. Lijun Liu, Yuling Zhu, Yufen Chen, Huiyu Chen, Cong Fan, Qiwen Mo, Jifeng Yuan*. One‐Pot Cascade Biotransformation for Efficient Synthesis of Benzyl Alcohol and Its Analogs. Chemistry - An Asian Journal, 2020, 15(7),1018-1021
26. Yang Zhang*, Jifeng Yuan*, Liejing Guo. Enhanced bio-hydrogen production from cornstalk hydrolysate pretreated by alkaline-enzymolysis with orthogonal design method. International Journal of Hydrogen Energy, 2020, 45(6),3750-3759
27. Jifeng Yuan, Benedict Ryan Lukito, Zhi Li*. De novo synthesis of (S)- and (R)-phenylethanediol in yeast via artificial enzyme cascades. ACS Synthetic Biology, 2019, 8(8), 1801-1808
28. Jifeng Yuan*, Xue Chen, Pranjul Mishra, Chi-Bun Ching. Metabolically engineered budding yeast for enhanced production of isoamyl alcohol. Applied Microbiology and Biotechnology. 2017, 101(1):465-475
29. Jifeng Yuan*, Chi-Bun Ching. Mitochondrial acetyl-CoA utilization pathway for terpenoid productions. Metabolic Engineering. 2016, 38:303-308
30. Jifeng Yuan*, Pranjul Mishra, Chi-Bun Ching. Metabolically engineered Saccharomyces cerevisiae for branched-chain ester productions. Journal of Biotechnology. 2017; 239:90-97
31. Wen Xu#, Jifeng Yuan*#, Shuiyun Yang, Chi-Bun Ching, Jiankang Liu. Programming saposin-mediated compensatory metabolic sinks for enhancing ubiquinone productions. ACS Synthetic Biology. 2016, 5(12):1404-1411
32. Jifeng Yuan*, Pranjul Mishra, Chi-Bun Ching. Engineering the leucine biosynthetic pathway for isoamyl alcohol production in budding yeast. Journal of Industrial Microbiology and Biotechnology. 2016, 44(1):107-117
33. Jifeng Yuan*, Chi-Bun Ching. Dynamic control of ERG9 expression for improved amorpha-4,11-diene production in Saccharomyces cerevisiae. Microbial Cell Factories. 2015, 14, 38
34. Jifeng Yuan*, Chi-Bun Ching. Combinatorial assembly of large biochemical pathways into yeast chromosomes for improved production of value-added compounds. ACS Synthetic Biology. 2015, 4(1):23-31
35. Jifeng Yuan*, Chi-Bun Ching. Combinatorial engineering of mevalonate pathway for improved amorpha-4,11-diene production in budding yeast. Biotechnology and Bioengineering. 2014, 111(3):608-617
36. Jifeng Yuan*, Hongcai Gao, Jianjun Sui, Hongwei Duan, Wei Ning Chen, Chi-Bun Ching. Cytotoxicity evaluation of oxidized single-walled carbon nanotubes and graphene oxide on human hepatoma HepG2 cells: An iTRAQ-coupled 2D LC-MS/MS proteome analysis. Toxicological Sciences. 2012, 126(1):149-156
37. Jifeng Yuan*, Hongcai Gao, Chi-Bun Ching. Comparative protein profile of human HepG2 cells treated with graphene and single-walled carbon nanotubes: An iTRAQ-coupled 2D LC-MS/MS proteome analysis. Toxicology Letters. 2011, 15; 207(3); 213-221
38. Jifeng Yuan*, Hongcai Gao, Jianjun Sui, Wei Ning Chen, Chi-Bun Ching. Cytotoxicity of single-walled carbon nanotubes on human hepatoma HepG2 cells: an iTRAQ-coupled 2D LC-MS/MS proteome analysis. Toxicology In Vitro. 2011, 25(8): 1820-1827